Let's make this birthday one to remember.

46 years old (Born on November 24, 1978)

Happy birthday, Katherine Heigl! You've gracefully navigated everything from alien teen drama as Isabel Evans in "Roswell" to handling surgical chaos and heart-wrenching romances as Izzy Stevens on "Grey's Anatomy." Life lessons learned: apparently, aliens are easier patients than medical interns.

Whether you're breaking hearts or fixing them onscreen, your performances have consistently won audiences' affection—earning you laughs, tears, and even an Emmy along the way. May your special day be filled with cake calories that don't count (Izzy would approve), countless smiles, and perhaps fewer dramatic hospital moments. Here's wishing this year brings another unforgettable chapter your way!